Related Experiment Video

Updated: Aug 11, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

Vesicoureteral reflux: a new treatment algorithm

Arne Stenberg1, Terry W Hensle, Göran Läckgren

  • 1Section of Urology, University Children's Hospital, S-75185 Uppsala, Sweden.

Current Urology Reports
|June 27, 2002
PubMed

Insights

Dextranomer/hyaluronic acid (Dx/HA) copolymer offers a safe and effective endoscopic treatment for persistent vesicoureteral reflux (VUR) in children. This approach provides a single-procedure cure, avoiding long-term antibiotics or major surgery.

Area of Science:

  • Pediatric Urology
  • Minimally Invasive Surgery
  • Biomaterials Science

Background:

  • Vesicoureteral reflux (VUR) affects 1% of children, increasing risks of pyelonephritis and kidney damage.
  • Current VUR treatments include antibiotic prophylaxis, open surgery, and endoscopic procedures.
  • Previous endoscopic materials raised safety and efficacy concerns.

Purpose of the Study:

  • To evaluate the safety and efficacy of dextranomer/hyaluronic acid (Dx/HA) copolymer for endoscopic VUR treatment.
  • To propose an updated treatment algorithm for persistent VUR in children.

Main Methods:

  • Review of emerging data on Dx/HA copolymer for VUR treatment.
  • Development of a new treatment algorithm based on established efficacy and safety.

Main Results:

  • Dx/HA copolymer demonstrates good long-term safety and efficacy in VUR treatment.
  • Endoscopic treatment with Dx/HA offers a single-procedure cure for VUR.

Conclusions:

  • Dx/HA copolymer is a viable alternative to prolonged antibiotic prophylaxis and open surgery for VUR.
  • A new algorithm recommends endoscopic treatment with Dx/HA for most children with persistent VUR.

More Related Videos

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...