Kidney pathology: current classification of renal cell carcinoma
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Updated: Sep 30, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Jonathan W Said1, George Thomas, Amnon Zisman
1Department of Pathology and Laboratory Medicine, University of California Los Angeles, CHS 13-226, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. jsaid@mednet.ucla.edu
Abstract:
This report discusses the new cytogenetic classification of renal cell carcinoma (RCC) and its biological and clinical significance. It describes the four major types (clear cell, chromophil, chromophobe, and collecting duct) as well as rarer entities, such as small cell carcinoma, cystic RCC, rhabdoid variant of RCC, and unclassified RCC. Sarcomatoid carcinomas are a diverse group representing high-grade transformation of the other types. In addition to a description of the pathologic findings, there is a discussion of tumor markers and prognostic indicators. The clinical significance of the classification is discussed, with reference to recent reports.
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