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Updated: Sep 30, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Dendritic cell-based immunotherapy of renal cell carcinoma
B J Gitlitz1, R A Figlin, A J Pantuck
1Medical Oncology, UCLA School of Medicine, 2345D PVUB, Box 7086, Los Angeles, CA 90095-7086, USA. bgitlitz@mednet.ucla.edu
Abstract:
Although mostly resistant to cytotoxic therapy, renal cell carcinoma has been a testing ground for immunotherapy. The approval of interleukin-2 for the treatment of renal cell carcinoma was a landmark "proof of principle" which showed that agents working solely via the immune system can cause durable cancer remission. Dendritic cells are central to immune-mediated surveillance and destruction of abnormal cells. They possess all the components required to educate immune effector cells that can then mediate tumor destruction. In vitro strategies to expand and load dendritic cells with antigens have now led to human vaccine trials in renal cell carcinoma and other malignancies.
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