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Cicerin and arietin, novel chickpea peptides with different antifungal potencies

X Y Ye1, T B Ng, P F Rao

  • 1Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Basic Medical Sciences Building, Shatin, NT, Hong Kong, China.

Peptides
|June 27, 2002
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...