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Thymosin alpha1 inhibits mammary carcinogenesis in Fisher rats
Terry W Moody1, Cynthia Tuthill, Mahnaz Badamchian
1Cell and Cancer Biology Branch, National Cancer Institute, 9610 Medical Center Drive, Building KWC, Rockville, MD 20850, USA. moodyt@bprb.nci.nih.gov
Abstract:
The effects of thymosin alpha1 (Talpha1) on mammary carcinogenesis was investigated in Fisher rats. Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats. Daily administration of Talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence and prolonged survival time. Animals treated with exogenous Talpha1 had a significantly greater blood white cell density than control Fisher rats. These results suggest that Talpha1 prevents mammary carcinoma incidence as a result of stimulation of the immune system.