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REM sleep and prolactin in patients with non-affective psychoses
Björn Appelberg1, Heikki Katila, Ranan Rimón
1Department of Psychiatry, Helsinki University Central Hospital, Lapinlahdentie, 00180, Finland. bjorn.appleberg@helsinki.fi
Abstract:
Reduced REM latency is a common polysomnographic finding in patients with schizophrenia. This has been attributed to cholinergic hyperactivity secondary to increased dopaminergic tone. We studied polysomnographic sleep recordings, and morning serum prolactin levels as a measure of dopaminergic tone in 17 drug-free patients suffering from non-affective psychoses, hypothesizing that REM-latency and prolactin would correlate. A clear-cut positive correlation between prolactin and REM latency was found, as well as a negative correlation between prolactin and REM sleep. The findings may be explained by dopaminergic and secondary hypercholinergic and/or serotonergic mechanisms responsible for the regulation of REM sleep and the secretion of prolactin.
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