Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain death impairs coronary endothelial function.

Gabor Szabo1, Volker Buhmann, Susanne Bahrle

  • 1Department of Cardiac Surgery, University of Heidelberg, Im Neueneheimer Feld 110, 69120 Heidelberg, Germany.

Transplantation
|June 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic comparison of commercial devices for temporal characterization of few-cycle laser pulses in the 500-1000 nm spectral range.

Optics express·2024
Same author

Chromatin as an old and new anticancer target.

Trends in cancer·2024
Same author

Life Years Gained From the FDA Accelerated Approval Program in Oncology: A Portfolio Model.

Journal of the National Comprehensive Cancer Network : JNCCN·2024
Same author

Diagnostic Accuracy of Transvaginal Ultrasound and Magnetic Resonance Imaging for the Detection of Myometrial Infiltration in Endometrial Cancer: A Systematic Review and Meta-Analysis.

Cancers·2024
Same author

HTK vs. HTK-N for Coronary Endothelial Protection during Hypothermic, Oxygenated Perfusion of Hearts Donated after Circulatory Death.

International journal of molecular sciences·2024
Same author

Transcriptomic Changes in the Myocardium and Coronary Artery of Donation after Circulatory Death Hearts following Ex Vivo Machine Perfusion.

International journal of molecular sciences·2024
Same journal

Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

Transplantation·2026
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
Same journal

Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

Transplantation·2026
See all related articles

Brain death (BD) impairs coronary blood flow and causes endothelial dysfunction, negatively impacting cardiac transplant outcomes. This study in canines reveals significant changes in coronary circulation and vasomotor response post-BD.

Area of Science:

  • Cardiovascular Physiology
  • Transplantation Immunology
  • Neurology

Background:

  • Brain death (BD) poses challenges in cardiac transplantation.
  • Endothelial dysfunction is a key concern in post-transplant outcomes.
  • Canine models are utilized to study BD's effects on cardiovascular function.

Purpose of the Study:

  • To investigate the impact of brain death (BD) on coronary circulation.
  • To characterize endothelial dysfunction following BD in a cardiac transplantation context.
  • To assess vasomotor function changes after BD induction.

Main Methods:

  • Utilized a canine model to induce brain death via subdural balloon inflation.
  • Continuously monitored left ventricular pressure-volume data and coronary blood flow (CBF).

Related Experiment Videos

  • Assessed endothelium-dependent (acetylcholine) and endothelium-independent (sodium nitroprusside) vasodilation before and after BD.

    • Main Results:

    • BD initially increased CBF, followed by a significant decrease after 3 hours.
    • Endothelium-dependent vasodilation shifted from monophasic response to initial vasodilation followed by vasoconstriction post-BD.
    • Endothelium-independent vasodilation remained unaffected by BD.

    Conclusions:

    • Brain death impairs coronary circulation, leading to decreased CBF and hemodynamic deterioration.
    • Severe endothelial dysfunction post-BD is a significant factor contributing to adverse post-transplant outcomes.
    • BD-induced endothelial dysfunction warrants further investigation in the context of organ transplantation.