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Erythrocyte mean corpuscular volume associated with severity of peripheral arterial disease: an angiographic

Meinhard Haltmayer1, Thomas Mueller, Christian Luft

  • 1Department of Laboratory Medicine, Konventhospital Barmherzige Brueder Linz, Linz, Austria. meinhard.haltmayer@bblinz.at

Annals of Vascular Surgery
|June 27, 2002
PubMed

Insights

Elevated mean corpuscular volume (MCV) is linked to more severe peripheral arterial disease (PAD). Higher MCV levels in patients with PAD correlate with greater atherosclerotic findings, suggesting MCV as a potential risk factor.

Area of Science:

  • Vascular Medicine
  • Cardiovascular Research
  • Hematology

Background:

  • Peripheral arterial disease (PAD) is a significant cause of morbidity.
  • Erythrocyte mean corpuscular volume (MCV) has been suggested as a potential risk factor for PAD.

Purpose of the Study:

  • To investigate the association between MCV and the severity of lower limb atherosclerosis in PAD patients.
  • To determine if MCV predicts angiographically assessed PAD severity.

Main Methods:

  • A study involving 100 male patients with symptomatic PAD.
  • Angiographic scoring system used to quantify atherosclerotic findings based on vessel lumen reduction.
  • Logistic regression analysis incorporating age, smoking, hypertension, MCV, homocysteine, total cholesterol, and triglycerides.

Main Results:

  • MCV showed a significant positive correlation with the angiographic score (rs = 0.247, p = 0.013).
  • Logistic regression identified MCV (OR = 2.02 per 5 fL increase) and age (OR = 2.41 per 10-year increase) as significant predictors of disease severity.
  • The model correctly classified 71% of subjects.

Conclusions:

  • MCV is associated with angiographically determined disease severity in patients with PAD.
  • The findings support the hypothesis that MCV is a risk factor for PAD.
  • The underlying mechanism linking MCV to PAD severity requires further investigation.

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