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Somatic glypican 3 (GPC3) mutations in Wilms' tumour
G R M White1, A M Kelsey, J M Varley
1Cancer Research UK Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
British Journal of Cancer
|June 27, 2002
Summary
Researchers screened Wilms
Area of Science:
- Pediatric Oncology
- Molecular Genetics
Background:
- Wilms' tumour is a common pediatric kidney cancer.
- Genetic factors are implicated in Wilms' tumour development.
Purpose of the Study:
- To investigate sequence variants in the glypican 3 (GPC3) gene in Wilms' tumour.
- To explore the potential role of GPC3 in the pathogenesis of Wilms' tumour.
Main Methods:
- Screening of tumour and normal tissue from 41 male Wilms' tumour cases.
- Analysis for sequence variants in the GPC3 gene.
Main Results:
- Two non-conservative single base changes were identified.
- These variants were exclusively found in tumour tissue.
Conclusions:
- The presence of GPC3 gene variants in tumour tissue suggests a potential role in Wilms' tumour development.
- GPC3 may be a contributing factor in the oncogenesis of Wilms' tumour.