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Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
Published on: June 14, 2014
Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
X Bu1, L Bernstein, R K Brynes
1Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.
Abstract:
Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.
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