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Related Experiment Videos

Prescribing patterns in premenstrual syndrome.

Katrina M Wyatt1, Paul W Dimmock, Martin Frischer

  • 1Exeter and North Devon RDSU, 1st floor Noy Scott House, Haldon View Terrace, Wonford Road, Exeter, UK. k.m.wyatt@ex.ac.uk

BMC Women'S Health
|June 28, 2002
PubMed
Summary

Prescribing for premenstrual syndrome (PMS) decreased significantly between 1993-1998. Progestogens remained the most prescribed treatment, despite limited evidence of effectiveness for PMS.

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Area of Science:

  • Reproductive Health
  • Pharmacovigilance
  • General Practice Research

Background:

  • Over 300 therapies exist for premenstrual syndrome (PMS).
  • Previous UK surveys on PMS treatments prescribed by GPs are limited, with the last in 1989.
  • Selective serotonin re-uptake inhibitors are now licensed for severe PMS/PMDD, and Vitamin B6 dosage recommendations have changed.

Purpose of the Study:

  • To investigate annual diagnosis rates and prescribing patterns for premenstrual syndrome (PMS) between 1993 and 1998.
  • To analyze trends in PMS treatment within a large, computerised general practitioner database.

Main Methods:

  • Retrospective survey of prescribing data for premenstrual syndrome (PMS).
  • Utilized the General Practice Research Database (GPRD) for the West Midlands Region.

Related Experiment Videos

  • Included data from 282,600 female patients over a five-year period (1993-1998).

    • Main Results:

    • The proportion of women with a prescription-linked diagnosis of PMS halved over the study period.
    • Progestogens (including progesterone) were the most prescribed PMS treatment (over 40%).
    • Selective serotonin re-uptake inhibitors (SSRIs) increased from 2% to over 16% of prescriptions, becoming the second most common treatment. Vitamin B6 prescriptions dropped from 22% to 11%.

    Conclusions:

    • A yearly decrease in PMS prescriptions linked to diagnoses was observed.
    • Progestogens remain the most widely prescribed PMS treatment, despite a lack of evidence for efficacy.
    • Prescribing patterns for PMS treatments have shifted, with increasing use of SSRIs and decreasing use of Vitamin B6.