Related Experiment Videos
Transcription repair coupling factor: a very pushy enzyme
1Cancer Research UK London Research Institute, Clare Hall Laboratory, South Mimms, EN6 3LD, UK.
Molecular Cell
|June 28, 2002
Abstract:
An irreversibly stalled RNA polymerase (RNAP) in the coding region of an active gene blocks transcription and can lead to the loss of genome integrity. A recent study of the bacterial Mfd protein (Park et al., 2002 [Cell volume 109]) provides new insight into mechanisms that release RNAP from sites of arrest such as noncoding DNA lesions.