Related Experiment Videos
Preparation of polymer-supported benzyllithium reagents
Shinichi Itsuno1, Satoshi Tanaka, Akira Hirao
1Department of Materials Science, Toyohashi University of Technology, Japan. itsuno@tutms.tut.ac.jp
Bioorganic & Medicinal Chemistry Letters
|June 28, 2002
Abstract:
Cross-linked polystyrenes (2, 8, and 11) possessing pendant double bonds conjugated with benzene ring were prepared by both polymerization method and chemical modification of pre-formed polymers. These double bonds were readily lithiated with n-butyllithium to give the benzyllithium species on the polymer. The polymer supported benzylic anions (3 and 12) are a versatile polymeric organometallic reagent that reacted with various kinds of electrophiles.