Related Experiment Video
Updated: Sep 30, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
A sugar-coated pacifier reduces procedural pain in newborns
1California State University, Fullerton Department of Nursing, Lake Forest, CA, USA.
Insights
A sugar-coated pacifier effectively reduces pain behaviors in newborns undergoing heelstick procedures. This intervention proved more effective than a water-moistened pacifier, sucrose solution, or no intervention for neonatal pain management.
Area of Science:
- Neonatal care
- Pain management
- Pediatric research
Background:
- Neonatal heelstick procedures are a common source of acute pain.
- Effective pain management strategies are crucial for infant well-being.
- Non-pharmacological interventions are increasingly explored for neonatal pain relief.
Purpose of the Study:
- To evaluate the effectiveness of pacifiers and sucrose for neonatal pain relief.
- To compare a sugar-coated pacifier, water-moistened pacifier, and oral sucrose solution.
- To determine the optimal intervention for managing pain during heelstick in neonates.
Main Methods:
- An experimental study involving 84 newborns undergoing heelstick.
- Random assignment to four groups: water-moistened pacifier, sugar-coated pacifier, oral sucrose solution, or control.
- Pain assessment included cry duration, vagal tone, and salivary cortisol levels.
Main Results:
- The sugar-coated pacifier group exhibited significantly reduced crying compared to water-moistened pacifier and control groups.
- Lower vagal tone was observed in the sugar-coated pacifier group versus oral sucrose and control groups.
- These pain-reducing effects of the sugar-coated pacifier persisted for 15 minutes post-procedure.
Conclusions:
- A sugar-coated pacifier is a superior intervention for reducing pain behaviors in neonates during heelstick.
- Compared to other methods, sugar-coated pacifiers offer more effective and sustained pain relief.
- This finding supports the use of sugar-coated pacifiers as a primary non-pharmacological pain management strategy for neonates.
Purpose:
To examine the efficacy of pacifiers and sugar, alone and in combination, for pain management in neonates.
Methods:
An experimental design examined pain responses of 84 newborns undergoing heelstick. They were randomly assigned to one of four groups: (a) water-moistened pacifier, (b) sugar-coated pacifier, (c) 2 cc of a 12% oral sucrose solution, or (d) control. Pain measures were duration of cry, vagal tone, and salivary cortisol.
Results:
Multivariate analysis of variance (MANOVA) revealed that the sugar-coated pacifier group cried significantly less than the water-moistened pacifier and control groups. Repeated measures analysis of variance (ANOVA) revealed that the sugar-coated pacifier group demonstrated significantly lower vagal tone during heelstick than the oral sucrose solution and control groups. This difference between the sugar-coated pacifier and control groups persevered for 15 minutes after heelstick.
Conclusions:
Offering a sugar coated pacifier during heelstick in healthy neonates reduces pain behaviors more effectively than a water-moistened pacifier, 2 cc of a 12% sucrose solution, or no intervention.
Related Concept Videos
Information-Processing Approach
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Parenteral Anesthetics: Overview
Local Anesthetics: Differential Sensitivity of Nerve Fibers

