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[Immunomodulating effect of lysozyme in acute cold stress]
A R Avakian1, A I Lazarev, L G Prokopenko
1Kursk State Medical University.
Summary
Lysozyme injections in rats demonstrated significant immune-modulating, antioxidant, and liver-protective effects, particularly during hypothermia. These benefits are linked to erythrocyte changes and spleen-derived cytokines.
Area of Science:
- Biochemistry
- Immunology
- Physiology
Context:
- Investigating the physiological effects of lysozyme in Wistar rats under hypothermic conditions.
- Examining the impact of cold immersion on immune response and organ function.
Purpose:
- To elucidate the immune-modulating, antioxidant, and hepatoprotective properties of lysozyme.
- To understand the mechanisms underlying lysozyme's effects, including erythrocyte aggregation and cytokine induction.
Summary:
- Lysozyme administration (1 or 5 mg/kg) to Wistar rats subjected to cold immersion induced notable immune modulation, antioxidant activity, and liver protection.
- The observed effects were attributed to the influence of lysozyme on erythrocytes and the induction of spleen cytokines, facilitated by glass-adhesion at 32-37°C.
Impact:
- Provides insights into potential therapeutic applications of lysozyme in managing hypothermia-related complications.
- Highlights the role of erythrocytes and spleen-derived cytokines in the biological activity of lysozyme.
- Establishes a foundation for further research into lysozyme's specific molecular pathways and clinical relevance.