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[Post-stroke depression: an experience in using cipramil].

A B Gekht, A N Bogolepova, I B Sorokina

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |June 29, 2002
    PubMed
    Summary
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    Cipramil (citalopram) effectively reduced depression in post-stroke patients. However, antidepressant effects diminished in some patients after treatment cessation, suggesting a need for longer treatment durations.

    Area of Science:

    • Neurology
    • Psychiatry
    • Pharmacology

    Background:

    • Depression is a common complication following stroke.
    • Post-stroke depression (PSD) significantly impacts patient recovery and quality of life.
    • Effective treatment strategies for PSD are crucial.

    Purpose of the Study:

    • To evaluate the efficacy of cipramil (citalopram) in treating depression in patients who have experienced a stroke.
    • To assess the impact of cipramil on neurological deficits in this patient population.

    Main Methods:

    • A randomized controlled trial involving 15 patients treated with cipramil (20 mg/day for 2.5 months) and 10 control patients.
    • Clinical examinations, computer tomography, Hamilton Rating Scale for Depression, and Lindmark Scale for neurological deficit were used.

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  • Patient state was evaluated before, during, and after treatment.

    • Main Results:

    • Cipramil significantly reduced depression scores on the Hamilton scale (p < 0.001) within 2-3 weeks, with sustained effect during treatment.
    • No significant changes were observed in neurological deficit scores.
    • Mild side effects occurred in 20% of patients, and antidepressant effects diminished in one-third within 1.5 months post-treatment.

    Conclusions:

    • Cipramil is effective in managing acute post-stroke depression.
    • The findings suggest a potential need for extended antidepressant treatment to maintain therapeutic benefits in post-stroke patients.
    • Further research into long-term treatment strategies for PSD is warranted.