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[Membrane destabilizing processes in perinatal nervous system disorders in children]
Insights
Perinatal encephalopathy in infants involves increased lipid peroxidation and decreased antioxidant defense. Treatments with antioxidant mexidol and lysosomal enzyme inhibitor contrical showed clinical and biochemical efficacy in infants with perinatal CNS damage.
Area of Science:
- Biochemistry
- Pediatrics
- Neurology
Background:
- Perinatal encephalopathy (PE) affects infants, impacting neurological development.
- Understanding biochemical alterations in PE is crucial for effective management.
Purpose of the Study:
- To investigate lipid peroxidation, antioxidant systems, lysosomal enzymes, and thrombocyte membrane phospholipids in infants with PE.
- To evaluate the clinical and biochemical efficacy of antioxidant and lysosomal enzyme inhibitor therapies in PE.
Main Methods:
- Prospective clinical and biochemical study of 252 infants during their first year of life.
- Analysis of lipid peroxidation, antioxidant system, lysosomal enzymes, and phospholipid compounds.
- Assessment of treatment effects with mexidol and contrical.
Main Results:
- Elevated lipid peroxidation and lysosomal enzyme activation observed in infants with PE.
- Decreased antioxidant defense levels were noted in the study group.
- Membrane destabilization correlated with hypoxic influence, severity, and clinical stage of PE.
Conclusions:
- PE is associated with significant biochemical changes, including oxidative stress and membrane instability.
- Mexidol and contrical demonstrate potential for treating perinatal CNS damage in infants.
- Further research is warranted to optimize therapeutic strategies for PE.
Abstract:
A complex prospective clinical and biochemical study was carried out in 252 children with perinatal encephalopathy during the 1st year of their life. The lipid peroxidation process, antioxidant system, lysosomal enzymes, phospholipid compound of thrombocyte membranes were studied. The lipid peroxidation process and lysosomal enzymes activation as well as a decrease of antioxidant defense level have been found. Membrane destabilization processes in the children with perinatal encephalopathy correlated with a character of hypoxic influence (acute, chronic, combined), a degree of severity and clinical manifestations of the pathology, and disease stage. Clinical and biochemical efficacy of antioxidant mexidol (0.1-0.2 ml/kg of the body weight intravenously for 10 days) and inhibitor of lysosomal enzymes contrical (1000 U/kg intravenously for 3-5 days) in the infants with perinatal CNS damages is claimed.