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Synthesis and trichomonacidal activity of perketals and hydroperoxides
L Cointeaux1, J F Berrien, B Camuzat-Dedenis
1Laboratoire de Chimie Organique, Faculté de Pharmacie, Châtenay-Malabry, France.
Farmaco (Societa Chimica Italiana : 1989)
|June 29, 2002
Abstract:
Some perketals were synthesized by the Dussault procedure using simple bromides and 2-methoxyprop-2-yl hydroperoxide. Treatment with acetic acid gave the corresponding hydroperoxides. Both perketals and hydroperoxides were tested in vitro as trichomonacidal agents. Most of them exhibited very good activities. The most powerful compound was 2-methoxyprop-2-yl hexadec-l-yl peroxide which exhibited an IC50 value of 0.51 microM being 10 times more effective than the reference compound Metronidazole.