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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue

L Brunetti1, I Cacciatore, A Di Stefano

  • 1Dipartimento di Scienze del Farmaco, Università degli Studi G D'Annunzio, Chieti, Italy.

Farmaco (Societa Chimica Italiana : 1989)
|June 29, 2002
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...