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Clinical predictors of early left ventricular thrombus formation in acute myocardial infarction

Csaba Tóth1, Erzsébet Ujhelyi, Tibor Fülöp

  • 1Department of Cardiology, Markhot Ferenc Hospital, Eger, Hungary.

Acta Cardiologica
|June 29, 2002
PubMed

Insights

Left ventricular thrombus formation after acute myocardial infarction is linked to anterior infarction and aneurysms. Early hospitalization significantly reduces this risk, aiding in individualized patient assessment.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Medical Imaging

Background:

  • Acute myocardial infarction (AMI) poses significant risks, including the development of left ventricular thrombus (LVT).
  • Identifying risk factors for LVT is crucial for patient management and prognosis.

Purpose of the Study:

  • To retrospectively investigate clinical, epidemiological, and echocardiographic risk factors associated with LVT development in patients with AMI.
  • To identify parameters that predict increased or decreased risk of LVT formation.

Main Methods:

  • Retrospective analysis of 1833 consecutive patients treated for AMI over 10 years.
  • Transthoracic echocardiography performed approximately 65 hours post-admission.
  • Multivariate analysis to determine hazard ratios for LVT development.

Main Results:

  • LVT detected in 7.9% of patients.
  • Anterior infarction, left ventricular dilatation, dyskinesis, aneurysm, and reduced ejection fraction were associated with higher LVT frequency.
  • Early hospital admission, family history of infarction, and thrombolytic therapy were associated with lower LVT frequency.
  • Anterior infarction and aneurysm significantly increased LVT hazard ratios; early hospitalization and family history decreased it.

Conclusions:

  • Anterior myocardial infarction and the presence of an aneurysm are significant risk factors for LVT formation.
  • Early hospitalization is a protective factor against LVT development.
  • These identified parameters can aid in assessing individual LVT risk in clinical practice.
Abstract

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