Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caloric restriction mimetics: physical activity and body composition changes.

E T Poehlman1, A Turturro, N Bodkin

  • 1Department of Medicine, University of Vermont, Burlington 05405, USA. epoehlma@zoo.uvm.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|June 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of thigh muscle and adipose tissue in knee osteoarthritis progression in women: data from the Osteoarthritis Initiative.

Osteoarthritis and cartilage·2018
Same author

Longitudinal change in thigh muscle strength prior to and concurrent with symptomatic and radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative.

Osteoarthritis and cartilage·2017
Same author

Extramyocellular adipose tissue in type 2 diabetes.

Canadian journal of diabetes·2015
Same author

Cardiac allograft pathology: A comment on the problem of chronic rejection.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Acute humoral rejection.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Inverse correlation of serum inflammatory markers with metabolic parameters in healthy, Black and White prepubertal youth.

International journal of obesity (2005)·2013
Same journal

Correction to: Association of heatwave exposure and multimorbidity with depression trajectories among older adults: evidence from the China Health and Retirement Longitudinal Study.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

The association of frailty with age and lifespan in mice differs by strain and sex.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Association between Hearing Loss, Physical Activity, and Sedentary Behavior: A Nationally Representative Cross-Sectional Study in Chile.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Challenge-based ex vivo immune profiling reveals stimulus-dependent peripheral immune reprogramming in Alzheimer's disease.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Introduction to the special issue on the impact of climate change and air quality on human aging.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

State Racism Index and physical function: The REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
See all related articles

Dietary restriction extends lifespan and prevents disease. This review explores if physical activity and body composition changes can mimic or enhance these benefits in animals and humans.

Area of Science:

  • Gerontology
  • Metabolic research
  • Exercise physiology

Background:

  • Dietary restriction is the only known intervention to consistently extend lifespan and inhibit disease.
  • Understanding modulators of lifespan is crucial for aging research.

Purpose of the Study:

  • To investigate the role of physical activity and body composition changes in modulating lifespan.
  • To determine if these factors can replace or enhance dietary restriction's benefits.
  • To clarify the complexity of these stimuli and improve research interpretation.

Main Methods:

  • Review of existing evidence in experimental animals and humans.
  • Examination of specific contributions of physical activity and body composition to lifespan and age-related diseases.

Related Experiment Videos

  • Discussion of potential future animal and human intervention studies.

    • Main Results:

    • Physical activity and body composition changes may influence lifespan and disease progression.
    • The interplay between these factors and dietary restriction is complex.
    • Further research is needed to fully elucidate their roles.

    Conclusions:

    • Physical activity and body composition are potential dietary restriction mimetics.
    • Future studies should focus on clarifying their specific contributions and interactions.
    • This research area holds promise for developing strategies to promote healthy aging.