Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cryptosporidium dose-response studies: variation between hosts.

Peter F M Teunis1, Cynthia L Chappell, Pablo C Okhuysen

  • 1National Institute for Public Health and the Environment, BA Bilthoven, The Netherlands. Peter.Teunis@rivm.nl

Risk Analysis : an Official Publication of the Society for Risk Analysis
|June 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seroresponse to repeated infections with Salmonella enterica Typhi and Paratyphi A.

Epidemics·2025
Same author

Bezlotoxumab for the prevention of recurrent <i>Clostridioides difficile</i> infection for patients with cancer.

Annals of gastroenterology·2025
Same author

Ten Practical Tips for a Successful Presentation at an Infectious Disease Clinical Case Conference.

Open forum infectious diseases·2025
Same author

The impact of cancer-related diarrhea on changes in cancer therapy.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same author

Bacteroides ovatus alleviates dysbiotic microbiota-induced graft-versus-host disease.

Cell host & microbe·2024
Same author

A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024

Host susceptibility to Cryptosporidium parvum infection varies. Pre-existing anti-Cryptosporidium IgG levels influence infection probability, impacting quantitative risk analysis for water-borne illnesses.

Area of Science:

  • Parasitology
  • Immunology
  • Quantitative Risk Analysis

Background:

  • Cryptosporidium parvum causes water-borne gastrointestinal illness with significant host-to-host variation in susceptibility.
  • Previous studies indicate lower infectivity in individuals with high pre-existing anti-Cryptosporidium IgG levels.

Purpose of the Study:

  • To adapt the hit theory model of microbial infection to incorporate host immune status, specifically IgG levels.
  • To investigate the influence of pre-existing IgG levels on Cryptosporidium parvum infectivity.

Main Methods:

  • Adapted the hit theory model to include covariables related to host immune status.
  • Analyzed the relationship between pre-existing anti-Cryptosporidium IgG levels and infection probability.

Related Experiment Videos

Main Results:

  • The probability of infection by a single Cryptosporidium parvum oocyst is dependent on pre-existing IgG levels.
  • High IgG levels may be an epiphenomenon of recent infection rather than direct immune protection.

Conclusions:

  • Host IgG levels are a significant factor in Cryptosporidium parvum dose-response relationships.
  • Quantitative risk assessment for Cryptosporidium parvum can be improved by considering population IgG level distributions.
  • Further research can utilize serum banks to understand population-level susceptibility variations.