Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleeping sickness and the brain.

B Enanga1, R J S Burchmore, M L Stewart

  • 1Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Scotland, United Kingdom.

Cellular and Molecular Life Sciences : CMLS
|June 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The 15 year ankle arthroplasty experience in a university hospital.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2021
Same author

Mining for natural product antileishmanials in a fungal extract library.

International journal for parasitology. Drugs and drug resistance·2019
Same author

Why aren't we doing more to safeguard vulnerable adults from thermal injuries?

Burns : journal of the International Society for Burn Injuries·2013
Same author

In vitro bacterial fermentation of tropical fruit fibres.

Beneficial microbes·2013
Same author

The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.

Parasitology·2009
Same author

Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules.

Rapid communications in mass spectrometry : RCM·2008

Neuropathological mechanisms of sleeping sickness involve complex parasite-host interactions and blood-brain barrier compromise. New research on blood-brain barrier models is crucial for developing effective diagnostics and therapeutics for this neurological disease.

Area of Science:

  • Neuroscience
  • Parasitology
  • Pharmacology

Background:

  • Sleeping sickness involves complex neuropathological mechanisms and central nervous system involvement.
  • The integrity of the blood-brain barrier is compromised during late-stage disease, affecting neurological function.
  • Current diagnostic methods require invasive procedures, and therapeutic drug delivery is hindered by the blood-brain barrier.

Purpose of the Study:

  • To review current understanding of the neurological aspects of sleeping sickness.
  • To highlight the role of the blood-brain barrier in disease pathology and treatment.
  • To propose future research directions focusing on blood-brain barrier models.

Main Methods:

  • Literature review of recent progress in sleeping sickness neuropathology.

Related Experiment Videos

  • Analysis of the interaction between trypanosome parasites and the host nervous system.
  • Discussion of blood-brain barrier function and dysfunction in the context of the disease.

    • Main Results:

    • Sleeping sickness pathology is complex, involving circadian rhythm disturbances and compromised blood-brain barrier integrity.
    • Neurological dysfunction may be exacerbated by parasite factors or host immune responses.
    • Microscopic examination of cerebrospinal fluid is the gold standard for diagnosis, but drug penetration is limited.

    Conclusions:

    • Improved diagnostic and therapeutic strategies for sleeping sickness are urgently needed.
    • Manipulating the blood-brain barrier could enhance drug permeability or limit efflux.
    • Development of advanced blood-brain barrier models is essential for understanding parasite-drug interactions in the nervous system.