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New nitrogenous eudesmane-type compounds isolated from the Caribbean sponge Axinyssa ambrosia
Natalia V Petrichtcheva1, Carmenza Duque, Adriana Dueñas
1Departamento de Química, Universidad Nacional de Colombia, AA 14490, Bogotá, Colombia.
Journal of Natural Products
|June 29, 2002
Abstract:
Fractionation of an acetone-methanol (1:1) extract of the Caribbean marine sponge Axinyssa ambrosia yielded three new sesquiterpenes whose structures were established by spectroscopic methods as (4R*,5R*,7S*,10R*)-eudesm-11-en-4-ylamine hydrochloride (1), axinyssamine hydrochloride, (4R*,5R*,7S*,10R*)-4-isocyanatoeudesm-11-ene (3), and (4R*,5R*,7S*,10R*)-formamidoeudesm-11-ene (4). Compound 1 exhibited significant cytotoxic activity against cancer cells and was also active in a lethality test using polyps of the scleractinian coral Madracis mirabilis.