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Related Experiment Videos

Pulse pressure and age at menopause.

Riitta Luoto1, A Richey Sharrett, Marsha Eigenbrodt

  • 1NHLBI, NIH, Two Rockledge Centre 6701 Rockledge Drive, MSC 7934 Bethesda, 20892, USA. riitta.luoto@uta.fi

BMC Women'S Health
|June 29, 2002
PubMed
Summary

Early menopause (before age 45) may be linked to a small increase in pulse pressure, a marker of arterial stiffness. Further research is needed to confirm this association in women.

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Area of Science:

  • Cardiovascular Health
  • Reproductive Endocrinology

Background:

  • Arterial stiffness, indicated by pulse pressure (PP), is a key indicator of cardiovascular risk.
  • Menopause is a significant physiological transition in women's lives, potentially impacting cardiovascular health.

Purpose of the Study:

  • To investigate the association between early age at natural menopause and pulse pressure (PP).
  • To examine the relationship between menopausal age and changes in PP over time.

Main Methods:

  • Analysis of 2484 women from the Atherosclerosis Risk in Communities (ARIC) Study.
  • Cross-sectional and longitudinal assessments of pulse pressure in relation to chronological and menopausal age.
  • Exclusion of women using hormone replacement therapy or who had undergone hysterectomy.

Main Results:

  • Chronological age positively correlated with PP cross-sectionally.
  • Early menopause (age < 45) was associated with a slightly greater PP increase (8.4 mmHg) compared to later menopause (6.5 mmHg).
  • This difference was not statistically significant in normotensive women.

Conclusions:

  • Early menopause might contribute to increased arterial stiffness, though the effect appears modest.
  • Further investigation is required to fully elucidate the relationship between early menopause and arterial stiffness progression.

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