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Keratinocytes and cytokines.

A Gröne1

  • 1Institut für Tierpathologie, Universität Bern, Länggassstr. 122, 3012 Bern, Switzerland. andrea.groene@itpa.unibe.ch

Veterinary Immunology and Immunopathology
|June 29, 2002
PubMed
Summary

Keratinocytes, the main skin cells, produce numerous cytokines, including interleukins (IL) and tumor necrosis factor alpha (TNF). These cytokines play crucial roles in skin immunity and disease pathogenesis.

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Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • Skin is a recognized cytokine producer, with keratinocytes as key epidermal cells.
  • Keratinocytes produce a wide array of cytokines, including interleukins (IL) and tumor necrosis factor alpha (TNF).
  • While pro-inflammatory cytokine production by keratinocytes is well-studied, their roles in other functions are emerging.

Purpose of the Study:

  • To highlight keratinocytes as significant sources and targets of various cytokines.
  • To explore the roles of keratinocyte-derived cytokines in skin biology and disease.
  • To review the expression of cytokine receptors on keratinocytes.

Main Methods:

  • Review of existing literature on keratinocyte cytokine production.
  • Analysis of studies investigating cytokine expression in vitro and in vivo.
  • Examination of organotypic culture systems for studying keratinocyte cytokine roles.

Main Results:

  • Keratinocytes produce numerous cytokines, including IL-1, -6, -7, -8, -10, -12, -15, -18, -20, and TNF.
  • Keratinocyte-derived IL-7 and -15 are implicated in T-cell trafficking and cutaneous T-cell lymphoma.
  • Keratinocytes express receptors for cytokines like IL-4, -13, -17, and -2, indicating they are also cytokine targets.

Conclusions:

  • Keratinocytes are crucial players in skin's immune response through cytokine production and reception.
  • Further research using various models can elucidate the complex roles of keratinocyte cytokines in health and disease.
  • Understanding keratinocyte cytokine networks is vital for developing targeted therapies for skin conditions.

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