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Related Experiment Videos

How does Legionella pneumophila exit the host cell?

Maëlle Molmeret1, Yousef Abu Kwaik

  • 1Dept of Microbiology and Immunology, University of Kentucky Chandler Medical Center, Lexington, KY 40536-0084, USA.

Trends in Microbiology
|June 29, 2002
PubMed
Summary

Pathogen exit strategies are poorly understood. Pore-formation-mediated host cell lysis and egress by Legionella pneumophila and Leishmania offer a novel model for pathogen exit mechanisms.

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Area of Science:

  • Microbiology
  • Cell Biology
  • Pathogenesis

Background:

  • Intracellular pathogens invade host cells, establishing infections.
  • Mechanisms of host cell lysis and pathogen egress remain largely unknown.

Purpose of the Study:

  • To investigate the mechanisms of host cell cytolysis and pathogen egress.
  • To explore pore-formation-mediated lysis as a potential model for pathogen exit.

Main Methods:

  • Analysis of Legionella pneumophila and Leishmania interactions with host cells.
  • Investigation of temporal pore-formation and host cell lysis.

Main Results:

  • Demonstrated temporal pore-formation leading to host cell lysis and pathogen egress.

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  • Identified a potential conserved mechanism for intracellular pathogen exit.

    • Conclusions:

    • Pore-formation-mediated lysis presents a novel model for intracellular pathogen egress.
    • This mechanism may be applicable to other intracellular pathogens with cytolysin activity.