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Updated: Aug 10, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
Published on: May 21, 2012
The role of dendritic cells during Salmonella infection
1Department of Clinical Immunology, University of Göteborg, Guldhedsgatan 10, Göteborg, Sweden. mary-jo.wick@immuno.gu.se
Abstract:
One type of phagocytic antigen-presenting cell (APC) - the dendritic cell (DC) - may have specialized functions during infection with the bacterium Salmonella, including a possible role in transporting Salmonella across the intestinal barrier. In addition, changes in the number, localization and cytokine production of CD8alpha+, CD8alpha-CD4+ and CD8alpha-CD4- DC subsets occur during infection. DCs function in stimulating bacteria-specific T cells by direct presentation of Salmonella antigens and as bystander APCs. Studying the function of DCs during Salmonella infection provides insight into the capacity of these sophisticated APCs, which are a key link between innate and adaptive immunity, to initiate and modulate the immune response to a bacterial infection.
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