Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

On differences between immunity and immunological memory.

Rolf M Zinkernagel1

  • 1Institute for Experimental Immunology, University Hospital, Zurich, Switzerland. rolf.zinkernagel@pty.usz.ch

Current Opinion in Immunology
|June 29, 2002
PubMed
Summary

Immunological memory offers species-level benefits through antibody transmission and individual protection against persistent infections via T cell memory. While experimentally induced memory is antigen-independent, effective immunity relies on antigen recognition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What if protective immunity is antigen-driven and not due to so-called "memory" B and T cells?

Immunological reviews·2018
Same author

Immunological memory: lessons from the past and a look to the future.

Nature reviews. Immunology·2016
Same author

Immunological memory ≠ protective immunity.

Cellular and molecular life sciences : CMLS·2012
Same author

A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.

Nature immunology·2011
Same author

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.

Hepatology (Baltimore, Md.)·2010
Same author

Long-lasting immunity by early infection of maternal-antibody-protected infants.

European journal of immunology·2009

Area of Science:

  • Immunology
  • Evolutionary Biology
  • Infectious Disease

Background:

  • Immunological memory provides adaptive advantages.
  • Antibodies offer transgenerational immune benefits.
  • T cell memory aids in combating persistent infections.

Purpose of the Study:

  • To explore the evolutionary significance of immunological memory.
  • To differentiate the roles of antibody and T cell memory in species and individual survival.
  • To investigate the relationship between antigen dependence and immunological memory.

Main Methods:

  • Comparative analysis of antibody and T cell memory functions.
  • Review of existing literature on immunological memory.
  • Examination of antigen-dependent and independent memory maintenance.

Related Experiment Videos

Main Results:

  • Antibodies contribute to species-level immunity through maternal transmission.
  • T cell memory primarily supports individual host defense against chronic infections.
  • Experimental immunological memory can be antigen-independent, but protective immunity is antigen-dependent.

Conclusions:

  • Immunological memory has distinct evolutionary roles at species and individual levels.
  • The antigen-dependent nature of protective immunity is crucial for effective host defense.
  • Understanding these mechanisms is key to developing robust vaccines and therapies.