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[Nocardia isolated from the respiratory tract].
Revista De La Asociacion Argentina De Microbiologia
|January 1, 1975
Summary
Nocardia asteroides was identified in clinical samples using various cultivation and testing methods. Five patients were diagnosed with pulmonary nocardiosis, showing improvement with sulfa drugs.
Area of Science:
- Medical Microbiology
- Clinical Diagnostics
Context:
- Nocardia species are opportunistic pathogens that can cause serious infections.
- Accurate identification and characterization of Nocardia strains are crucial for effective treatment.
Purpose:
- To classify twelve Nocardia strains isolated from clinical specimens.
- To investigate the sensitivity of these strains to tuberculostatic drugs and rifamycin.
- To determine the pathogenicity of the isolated strains in guinea pigs.
Summary:
- Twelve Nocardia strains from sputum, bronchial washings, and pleural fluids were classified as Nocardia asteroides based on acid-fastness, enzymatic activity, and growth characteristics.
- Isolation utilized paraffin-bait and routine T.B. digestion techniques. Drug sensitivity testing included tuberculostatic drugs and rifampicin.
- Pathogenicity was assessed in guinea pigs. Five patients with pulmonary nocardiosis were diagnosed, showing clinical improvement with sulfa administration.
Impact:
- This study confirms Nocardia asteroides as a causative agent of pulmonary infections.
- Highlights the importance of specific diagnostic methods for Nocardia.
- Demonstrates the therapeutic efficacy of sulfa drugs in treating nocardiosis.