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Two administration methods for inhaled salbutamol in intubated patients
S S Garner1, D B Wiest, J W Bradley
1Department of Pharmacy Practice, Medical University of South Carolina, Charleston, South Carolina 29425, USA. garnerss@musc.edu
Archives of Disease in Childhood
|June 29, 2002
Summary
Inhaled salbutamol (a bronchodilator) delivered via small volume nebuliser (SVN) or metered dose inhaler (MDI) with a spacer showed comparable effects on respiratory mechanics and hemodynamics in infants and children.
Area of Science:
- Pediatric Pulmonology
- Respiratory Pharmacology
- Critical Care Medicine
Background:
- Inhaled bronchodilators are crucial for managing respiratory conditions in pediatric patients.
- Optimizing the delivery method of inhaled medications is essential for efficacy and safety in intubated children.
Purpose of the Study:
- To compare serum concentrations and physiological effects of salbutamol administered via small volume nebuliser (SVN) versus metered dose inhaler (MDI) with a spacer in intubated infants and children.
Main Methods:
- A blinded, randomized, crossover study involved 12 intubated infants and children.
- Salbutamol was administered at 0.15 mg/kg by SVN and 400 mcg by MDI plus spacer.
- Respiratory mechanics, serum salbutamol levels, and hemodynamics were measured at various time points.
Main Results:
- No significant differences were observed in the percentage change of respiratory mechanics or hemodynamics between SVN and MDI plus spacer.
- Mean area under the curve (AUC(0-4)) for serum salbutamol concentrations was similar between the two delivery methods.
Conclusions:
- Serum concentrations and effects on respiratory mechanics and hemodynamics of salbutamol are comparable between SVN and MDI plus spacer in intubated pediatric patients.
- Further research is needed to establish optimal dosing and delivery strategies for inhaled salbutamol in mechanically ventilated children.