Related Experiment Videos
Nature and nurture in vitamin B12 deficiency
J Zschocke1, S Schindler, G F Hoffmann
1Institute of Human Genetics, Heidelberg University, Germany. kawahara@pedsurg.med.osaka-u.ac.jp
Archives of Disease in Childhood
|June 29, 2002
Abstract:
We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate. Some patients with vitamin B12 deficiency may benefit from high dose folic acid supplementation, even if plasma concentrations are high.