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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Related Experiment Video

Updated: Feb 16, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

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Neural stem cells and neurodegeneration.

Alexander Storch1, Johannes Schwarz

  • 1Department of Neurology, University of Ulm, Germany. alexander.storch@medizin.uni-ulm.de

Current Opinion in Investigational Drugs (London, England : 2000)
|July 2, 2002
PubMed
Summary

Neural stem cells (NSC) offer a promising regenerative therapy for neurodegenerative diseases by replacing lost neurons. This review explores using NSC for treating conditions like Parkinson

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Neurodegenerative diseases involve progressive neuron loss, impacting functions.
  • Current treatments are limited, necessitating novel therapeutic strategies.
  • Neural stem cells (NSC) are key candidates for neural regeneration.

Purpose of the Study:

  • To review the potential of neural stem cells (NSC) in regenerative therapy for neurodegenerative diseases.
  • To highlight NSC's capacity for self-renewal and differentiation into neural cells.
  • To discuss the application of NSC in treating conditions like Parkinson's disease.

Main Methods:

  • Review of existing literature on neural stem cell transplantation and proliferation.
  • Analysis of NSC properties: self-renewal and differentiation potential.

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Enumeration of Neural Stem Cells Using Clonal Assays

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Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research
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Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research

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Last Updated: Feb 16, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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Enumeration of Neural Stem Cells Using Clonal Assays
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Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research
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  • Focus on in vitro culture and in vivo application of NSC for CNS repair.

    • Main Results:

    • NSC can be cultured in vitro while maintaining their differentiation potential.
    • Transplantation of NSC or induction of endogenous NSC proliferation are viable regenerative approaches.
    • NSC can generate diverse neural cell types essential for CNS function.

    Conclusions:

    • Neural stem cells (NSC) represent a significant therapeutic avenue for neurodegenerative disorders.
    • Regenerative strategies involving NSC hold promise for restoring neural function.
    • Further research into NSC-based therapies is crucial for clinical translation.