Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular autonomic function in systemic lupus erythematosus.

M B Hogarth1, L Judd, C J Mathias

  • 1Rheumatology Unit, Imperial College School of Medicine, St Mary's Hospital, London, UK. m.b.hogarth@btinternet.com

Lupus
|July 2, 2002
PubMed
Summary

Cardiovascular autonomic function may be impaired in patients with systemic lupus erythematosus (SLE). Many SLE patients experience symptoms linked to autonomic dysfunction, suggesting a need for assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In at the deep end: the physiological challenges associated with artistic swimming.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2024
Same author

Twenty-four-hour ambulatory blood pressure and heart rate profiles in diagnosing orthostatic hypotension in Parkinson's disease and multiple system atrophy.

European journal of neurology·2016
Same author

Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2015
Same author

Central defects of autonomic function in secondary progressive multiple sclerosis: observations based on cardiovascular and growth hormone responses to clonidine.

European journal of neurology·2013
Same author

Pure autonomic failure with cold induced sweating.

Autonomic neuroscience : basic & clinical·2013
Same author

Headache in three new cases of Harlequin syndrome with accompanying pharmacological comparison with migraine.

Journal of neurology, neurosurgery, and psychiatry·2012

Area of Science:

  • Immunology
  • Cardiology
  • Neurology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with potential multi-organ involvement.
  • Cardiovascular complications are a significant concern in SLE patients.
  • Autonomic nervous system dysfunction has been anecdotally reported in SLE.

Purpose of the Study:

  • To investigate whether cardiovascular autonomic function is impaired in individuals diagnosed with SLE.
  • To compare autonomic function between SLE patients and a healthy control group.

Main Methods:

  • A case-control study involving 23 patients with SLE and a control group.
  • Assessment of autonomic symptoms via a standardized questionnaire.
  • Measurement of cardiovascular autonomic function using 10 non-invasive tests.

Related Experiment Videos

  • Analysis of plasma adrenaline and noradrenaline levels.

    • Main Results:

    • Significant differences in cardiovascular autonomic function were observed between SLE patients and controls in three out of 24 tested parameters.
    • Specifically, reduced systolic blood pressure during head-up tilt and altered heart rate responses to isometric exercise and cold pressor tests were noted in SLE patients.
    • Eleven SLE patients (48%) exhibited abnormal heart rate, blood pressure, or Valsalva responses, compared to six controls.
    • Plasma catecholamine levels (adrenaline and noradrenaline) were significantly lower in SLE patients.
    • Twenty-one SLE patients (91%) reported symptoms potentially related to autonomic dysfunction, though symptom count did not correlate with objective autonomic impairment.

    Conclusions:

    • Cardiovascular autonomic impairment can be demonstrated in a subset of patients with SLE.
    • Symptoms suggestive of autonomic dysfunction are prevalent in SLE.
    • Routine autonomic function assessment may be warranted for SLE patients to identify potential impairment.