Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temporal lobe abnormalities in first-episode psychosis.

Alex Sumich1, Xavier A Chitnis, Dominic G Fannon

  • 1Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK.

The American Journal of Psychiatry
|July 2, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid Decoupled Electrochemical Reduction of CO<sub>2</sub> to Syngas.

ChemSusChem·2026
Same author

Intracellular trafficking and nuclear compartmentalization of AAV gene delivery.

Molecular therapy. Advances·2026
Same author

AAV2 Crosslinks Actin Filaments: Implications for AAV Gene Therapy Vector Design.

bioRxiv : the preprint server for biology·2026
Same author

Homogeneous redox catalysed reduction of CO<sub>2</sub> by nickel cyclam catalyst and chromium-based redox mediator.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

The effects of 12 weeks of chiropractic spinal adjustments on physiological biomarkers in adults: A pragmatic randomized controlled trial.

PloS one·2025
Same author

Long-distance remote epitaxy.

Nature·2025

Early psychosis is associated with smaller temporal lobe structures, including the hippocampus and planum temporale. These findings suggest structural brain abnormalities are present at the onset of psychotic illness.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Temporal lobe abnormalities in psychotic illness are debated, with factors like chronicity, gender, and handedness causing confounding variables.
  • Investigating early-stage psychosis is crucial to understand the fundamental neuropathology.

Purpose of the Study:

  • To investigate temporal lobe substructure volumes in right-handed male patients during their first episode of psychotic illness.
  • To identify potential early neuroanatomical markers associated with the onset of psychosis.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) to assess brain structures.
  • Compared 25 first-episode psychosis patients (minimally treated) with 16 healthy controls.
  • Measured and compared volumes of the hippocampus, amygdala, planum temporale, and Heschl's gyrus.

Related Experiment Videos

Main Results:

  • Patients exhibited reduced bilateral hippocampal and left planum temporale volumes compared to controls.
  • Significant differences in left amygdala volume were observed between paranoid and nonparanoid patients.
  • These volumetric differences were detected near the onset of psychosis.

Conclusions:

  • Bilateral hippocampal and left planum temporale abnormalities are evident at the early stages of psychosis.
  • These findings contribute to understanding the neurobiological underpinnings of psychotic disorders.
  • Structural brain changes may serve as early indicators in psychotic illness.