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Repetitive ischemia-induced injury in microcirculation of the rabbit spinal cord

E Mechírová1, L Zachariás, I Domoráková

  • 1Department of Histology and Embryology, Medical Faculty of P. J. Safárik University, Srobárova 2, 040 00 Kosice, Slovak Republic.

Sbornik Lekarsky
|July 3, 2002
PubMed
Abstract

No abstract available in PubMed .

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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