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Original method for nicorandil synthesis.

M Ungureanu1, G Dănilă

  • 1School of Medical Bioengineering, Gr.T. Popa University of Medicine and Pharmacy, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|July 3, 2002
PubMed
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A new method synthesizes Nicorandil, a vasodilator, using readily available ethyl nicotinate. This approach yields high-purity Nicorandil affordably from indigenous materials, improving accessibility.

Area of Science:

  • Pharmaceutical Chemistry
  • Medicinal Chemistry

Background:

  • Nicorandil is a vasodilator drug that activates potassium channels.
  • Current synthesis methods may rely on expensive or imported precursors.

Purpose of the Study:

  • To develop a cost-effective and efficient synthesis method for Nicorandil.
  • To utilize indigenous raw materials for Nicorandil production.

Main Methods:

  • The study proposes a new synthesis route for Nicorandil.
  • Ethyl nicotinate is used as the primary raw material.
  • The synthesis involves treating ethyl nicotinate with specific reagents in an organic solvent.

Main Results:

  • The proposed method yields Nicorandil with high purity.

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  • The synthesis process demonstrates a good overall yield.
  • The cost of production is reduced by using indigenous raw materials.

    • Conclusions:

    • The novel synthesis method offers an economical and efficient way to produce Nicorandil.
    • This approach enhances the availability of Nicorandil by using accessible, indigenous resources.