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[Imidazoline receptors-normal and pathological factors]
1Facultatea de Medicină Stomatologică, Catedra de Farmacologie, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
Imidazolinic receptors I1 and I2A and I2B different from alpha 2 receptors and by any other type of receptors were identified in the last years in many tissues from human body and in cells of a great number of animals. There are agonists and antagonists on I1 receptors (e.g., agonists like moxonidine, rilmenidine and antagonists like efaroxan, BAF 6143 etc.) and also on I2 receptors (e.g., agonist-idazoxan, etc.). There are many actions performed by stimulation of imidazolinic receptors like: decreasing of blood pressure (I1 stimulation from midbrain), decreasing of noradrenaline plasmatic level, antiarrhythmic actions in experimental arrhythmias etc. Imidazolinic receptors are involved in natriuresis, pancreatic insulin production, some superior nervous activities, regulation of food intake etc. We consider that imidazolinic receptors and their endogenous agonists (e.g. agmatine) represent an important system involved in modulation of cell function.
Imidazolinic receptors I1 and I2A and I2B different from alpha 2 receptors and by any other type of receptors were identified in the last years in many tissues from human body and in cells of a great number of animals. There are agonists and antagonists on I1 receptors (e.g., agonists like moxonidine, rilmenidine and antagonists like efaroxan, BAF 6143 etc.) and also on I2 receptors (e.g., agonist-idazoxan, etc.). There are many actions performed by stimulation of imidazolinic receptors like: decreasing of blood pressure (I1 stimulation from midbrain), decreasing of noradrenaline plasmatic level, antiarrhythmic actions in experimental arrhythmias etc. Imidazolinic receptors are involved in natriuresis, pancreatic insulin production, some superior nervous activities, regulation of food intake etc. We consider that imidazolinic receptors and their endogenous agonists (e.g. agmatine) represent an important system involved in modulation of cell function.