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[Fertility in prolactinomas--considerations concerning some clinical cases]
O Ionescu1, C Vulpoi, M C Ungureanu
1Facultatea de Medicină, Clinica Endocrinologică, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
Summary
Hyperprolactinemia due to prolactinoma frequently causes infertility in women. This study shows that infertility linked to prolactinoma is reversible with treatment, often restoring fertility and leading to normal pregnancies.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Oncology
Background:
- Prolactinoma, a common endocrine disorder, is a significant cause of infertility in women.
- Elevated prolactin levels (hyperprolactinemia) disrupt normal reproductive function.
Purpose of the Study:
- To evaluate the association between female fertility and hyperprolactinemia caused by prolactinoma.
- To assess the reversibility of infertility and pregnancy outcomes in women with prolactinoma.
Main Methods:
- Retrospective analysis of 113 women with prolactinoma, focusing on 83 women of reproductive age (18-45 years).
- Diagnosis confirmed by clinical symptoms (amenorrhea-galactorrhea, infertility), biological tests (prolactin levels), and morphological imaging (pituitary CT).
- Categorization of patients based on the relationship between prolactinoma diagnosis and pregnancy status.
Main Results:
- Infertility associated with prolactinoma was found to be reversible with treatment in 8.9% of cases.
- Nine patients conceived after hyperprolactinemia treatment, achieving normal pregnancies and delivering healthy children.
- Lowering prolactin levels was crucial for restoring ovulation and enabling conception.
Conclusions:
- Infertility in women with prolactinoma is often reversible through appropriate treatment aimed at normalizing prolactin levels.
- Treatment for hyperprolactinemia, such as bromocriptine, appears safe during pregnancy, with most cases showing successful outcomes.