Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Type 1A diabetes mellitus-associated autoimmunity.

Edwin Liu1, George S Eisenbarth

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave., Denver, CO 80262, USA.

Endocrinology and Metabolism Clinics of North America
|July 3, 2002
PubMed
Summary

Type 1A diabetes mellitus prediction is possible by identifying human leukocyte antigen (HLA) genetic susceptibility and specific anti-islet autoantibodies. Early detection of these markers aids in predicting disease progression and associated autoimmune disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unsedated Transnasal Esophagogastroduodenoscopy for Evaluation of Celiac Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Assessment of a standard dietitian evaluation in pediatric patients with celiac disease.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same author

Ironing Out the Deficiency: Tracking Iron in Celiac Disease Before and After the Gluten-Free Diet.

Nutrients·2026
Same author

Psychometric Evaluation of the Celiac Disease Symptom Diary 2.1<sup>©</sup> Using Data from the Virtual Celiac Symptoms Study.

Patient related outcome measures·2026
Same author

Cost-Effectiveness Models for Celiac Disease Mass Screening Are Encouraging, but Policy Makers Need More.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Mass Screening of Celiac Disease: A Crossing Point Between Secondary and Primary Prevention?

Gastroenterology·2025

Area of Science:

  • Immunology and Endocrinology
  • Autoimmune Disease Research

Background:

  • Type 1A diabetes mellitus is a leading autoimmune disorder with established animal models and prospective human studies.
  • Genetic susceptibility, particularly HLA-encoded factors, plays a crucial role in the development of type 1A diabetes.

Purpose of the Study:

  • To review the current understanding of autoimmune disorders associated with type 1A diabetes mellitus.
  • To highlight the predictive markers for type 1A diabetes, including genetic predisposition and autoantibodies.

Main Methods:

  • Utilized international workshops to develop sensitive radioassays for detecting autoantibodies against islet antigens like GAD65, ICA512, and insulin.
  • Applied high-throughput radioassays for autoantigens in other autoimmune conditions such as celiac and Addison's disease.

Related Experiment Videos

Main Results:

  • Prediction of type 1A diabetes is feasible through identification of HLA genetic susceptibility and a series of anti-islet autoantibodies.
  • Relatives of type 1A diabetes patients show inherited susceptibility to multiple autoantibodies, with a subset progressing to overt disease.

Conclusions:

  • Early prediction of type 1A diabetes is achievable by detecting specific autoantibodies and genetic markers.
  • Understanding associated autoimmune disorders is crucial for comprehensive patient management and research.