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Related Experiment Videos

Living longer--but better?

Bernard Jeune1

  • 1Institute of Public Health, and Ageing Research Center, University of Southern Denmark, Odense. bjeune@health.sdu.dk

Aging Clinical and Experimental Research
|July 3, 2002
PubMed
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Improved cardiovascular profile in Danish centenarians? A comparative study of two birth cohorts born 20 years apart.

European geriatric medicine·2022

Human lifespan has significantly increased, with more individuals reaching extreme old age. While centenarians are survivors, their health status varies, influenced by genetics and lifestyle factors.

Area of Science:

  • Gerontology
  • Demography
  • Genetics

Background:

  • The maximum human lifespan has increased by approximately 20 years since the 19th century.
  • The number of individuals aged 115 and above, including Jeanne Calment at 122, has risen.
  • Centenarian populations in low-mortality countries have doubled each decade since 1950.

Purpose of the Study:

  • To examine the trends and factors influencing extreme human longevity.
  • To investigate the health status and survival mechanisms of centenarians.
  • To understand the implications of increased longevity on society.

Main Methods:

  • Analysis of demographic data on aging and mortality rates.
  • Review of studies on centenarian health, comorbidity, and genetics (e.g., apoE gene).

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  • Exploration of potential personality traits and biological functions in long-livers.

    • Main Results:

    • Increased longevity is primarily attributed to reduced elderly mortality.
    • Centenarians often exhibit comorbidity but may experience less severe conditions than younger elderly.
    • Genetic factors and potentially preserved biological/cognitive functions play a role in reaching extreme old age.

    Conclusions:

    • While living longer, centenarians' health is complex, involving both challenges and resilience.
    • Genetic predispositions and potentially advantageous traits contribute to exceptional longevity.
    • The proportion of autonomous long-livers is expected to increase, potentially delaying dependency in old age.