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A multiantioxidant supplementation reduces damage from ischaemia reperfusion in patients after lower torso ischaemia.
M H W A Wijnen1, R M H Roumen, H L Vader
1Department of Surgery, St. Joseph Hospital, Veldhoven, 5500 MB, The Netherlands.
Background:
open repair of intra-abdominal aortic aneurysm (AAA) is associated with lower torso ischaemia and reperfusion.
Objective:
to examine the effect of antioxidants on the activation and sequestration of white blood cells and muscle injury during AAA repair.
Method:
forty-two patients undergoing elective infrarenal aneurysm repair, were randomised to either standard therapy (22 patients) or standard therapy with additional multiantioxidant supplementation (20 patients). Vitamin E and C, Allopurinol, N-acetylcysteine and mannitol was administered perioperatively. White blood cell count (WBC), serum creatine kinase, aspartateaminotransferase, lactate and lipofuscine were measured.
Results:
WBC remained higher after reperfusion in the antioxidant group (p = 0.008). CK, ASAT and lipofuscine levels were significantly lower after reperfusion in the antioxidant group (p = 0.02, p = 0.018, p = 0.017).
Conclusion:
multi-antioxidant supplementation was associated with a reduction in serum CK and ASAT after AAA repair. This is likely due to a reduction in oxidative stress and a decreased leucocyte sequestration and activation.