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Homocysteine, vitamin B(6), and lipid in cardiovascular disease
Sue-Joan Chan1, Chen-Nen Chang, Jee-Ching Hsu
1Department of Biology, National Cheng Kung University, Tainan, Taiwan 701, R.O.C. sjchang@mail.ncku.edu.tw
Insights
Patients with cardiovascular disease (CVD) have higher plasma homocysteine (Hcy) levels, influenced by sex, age, and body composition, not vitamin B6 or lipid profiles. This finding highlights key factors associated with elevated Hcy in CVD patients.
Area of Science:
- Cardiovascular Disease Research
- Biochemistry
- Nutritional Science
Background:
- Elevated homocysteine (Hcy) is an independent risk factor for cardiovascular disease (CVD).
- High plasma Hcy may exacerbate vascular disease risk when interacting with other CVD risk factors.
- Understanding Hcy levels in CVD patients is crucial for risk assessment and management.
Purpose of the Study:
- To investigate plasma Hcy levels in patients with CVD.
- To examine the relationship between Hcy, vitamin B6 status, and lipid profiles in CVD patients.
- To identify factors influencing plasma Hcy levels in individuals with cardiovascular disease.
Main Methods:
- Assessed plasma Hcy, vitamin B6 status (pyridoxal phosphate, pyridoxal), and lipid profiles in CVD patients and controls.
- Analyzed associations between sex, age, body mass index (BMI), and waist-to-hip ratio (WHR) with plasma Hcy levels.
- Correlated plasma Hcy with vitamin B6 status and lipid profiles.
Main Results:
- Patients with CVD exhibited significantly higher plasma Hcy, BMI, and WHR compared to controls.
- Male CVD patients had higher plasma Hcy and vitamin B6 levels than female patients.
- Plasma Hcy levels did not correlate with vitamin B6 status or lipid profiles but positively correlated with age, BMI, and WHR.
Conclusions:
- CVD patients demonstrate elevated plasma Hcy levels.
- Plasma Hcy in CVD patients is influenced by sex, age, BMI, and WHR.
- Vitamin B6 status and lipid profiles do not appear to influence plasma Hcy levels in this CVD cohort.
Objectives:
Elevated homocysteine (Hcy) is considered an independent risk factor for cardiovascular disease (CVD). An elevated plasma Hcy level may interact with conventional CVD risk factors to further increase vascular disease risk. Therefore, we investigated the plasma levels of Hcy, vitamin B(6) status (pyridoxal phosphate and pyridoxal), and lipid profile in patients with CVD.
Methods:
Possible associations between sex, age, body mass index (BMI), and waist-to-hip ratio (WHR) to levels of plasma Hcy and plasma Hcy to vitamin B(6) status and lipid profile were examined.
Results:
Plasma Hcy level, body mass index, and waist-to-hip ratio were significantly higher in patients with CVD than in controls. Male CVD patients had significantly higher plasma Hcy levels than did female patients. Plasma levels of pyridoxal phosphate and total B(6) aldehyde were significantly higher in male than in female patients. Plasma Hcy levels of patients did not correlate to their plasma vitamin B(6) status or to their lipid profiles. Plasma Hcy level correlated positively with age, body mass index, and waist-to-hip ratio (P < 0.0001).
Conclusions:
This suggested that patients with CVD have higher levels of plasma Hcy that are influenced by sex, age, body mass index, and waist-to-hip ratio and not by their plasma vitamin B(6) status and lipid profiles.