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Aggression escalated by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition

Rosa M M de Almeida1, Klaus A Miczek

  • 1Departments of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
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Summary

The 5-HT1B receptor agonist anpirtoline effectively reduced escalated aggression in mice, including aggression triggered by social instigation or frustration. These anti-aggressive effects were blocked by a specific antagonist, confirming the 5-HT1B receptor

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Animal Behavior

Background:

  • Serotonergic mechanisms are implicated in escalated aggression.
  • 5-HT1B receptor agonists demonstrate anti-aggressive properties in various aggression levels.

Purpose of the Study:

  • To investigate the effects of the 5-HT1B agonist anpirtoline on different forms of aggression in male mice.
  • To determine if anpirtoline's anti-aggressive effects are mediated by the 5-HT1B receptor.

Main Methods:

  • Administered anpirtoline (0.125-1.5 mg/kg) to male mice to assess effects on species-typical, instigated, and frustration-heightened aggression.
  • Evaluated motor behavior to rule out non-specific effects.
  • Assessed anpirtoline's effects after pretreatment with the 5-HT1B/1D receptor antagonist GR127935 (10 mg/kg).

Main Results:

  • Anpirtoline significantly decreased both instigated and frustration-heightened aggression.
  • Motor behavior remained unaffected by anpirtoline administration.
  • The aggression-inhibiting effects of anpirtoline were blocked by pretreatment with GR127935.

Conclusions:

  • The 5-HT1B receptor plays a critical role in modulating escalated aggression.
  • Anpirtoline, a 5-HT1B agonist, exhibits specific anti-aggressive effects independent of motor activity changes.