Early management of craniosynostosis using endoscopic-assisted strip craniectomies and cranial orthotic molding therapy
Related Experiment Video
Updated: Aug 9, 2026

Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants
Published on: May 23, 2020
David F Jimenez1, Constance M Barone, Cathy C Cartwright
1Department of Neurological Surgery, Center for Craniofacial Disorders, University of Missouri Hospital and Clinics, Columbia, Missouri 65212, USA. jimenezd@health.missouri.edu
Insights
Early endoscopic strip craniectomies offer a safe and effective treatment for infant craniosynostosis. This minimally invasive approach leads to excellent outcomes with reduced complications compared to traditional surgery.
Area of Science:
- Pediatric Neurosurgery
- Craniofacial Surgery
- Minimally Invasive Surgery
Background:
- Craniosynostosis, the premature fusion of cranial sutures, requires timely intervention to ensure proper brain development and skull growth.
- Traditional surgical methods for craniosynostosis involve extensive open procedures with significant risks and prolonged recovery times.
Purpose of the Study:
- To evaluate the safety, efficacy, and outcomes of early treatment for craniosynostosis using minimally invasive endoscopic strip craniectomies.
- To assess the effectiveness of postoperative helmet molding therapy in conjunction with the surgical intervention.
Main Methods:
- A prospective study of 100 infants diagnosed with craniosynostosis treated with endoscopic strip craniectomies.
- Operations were performed on 106 sutures (sagittal, coronal, metopic, lambdoid), with 63 patients treated before 16 weeks of age.
- Postoperative management included custom-made molding helmets for up to 7 months, with follow-up ranging from 4 to 50 months.
Main Results:
- All procedures were completed successfully without intraoperative complications.
- Minimal blood loss (mean 26.2 mL) and operative time (mean 52.7 minutes) were observed, with few patients requiring blood transfusions.
- No infections, cerebrospinal fluid leaks, or neurological injuries occurred; helmet therapy also showed no significant complications. Most patients achieved normalized craniofacial development.
Conclusions:
- Early endoscopic strip craniectomies represent a safe and effective alternative to traditional open surgery for craniosynostosis.
- This minimally invasive technique offers reduced blood loss, fewer transfusions, shorter hospital stays, and decreased costs, making it an advantageous early treatment option.
Objective:
To assess the safety, efficacy, and results of the early treatment of infants with craniosynostosis using minimally invasive endoscopic strip craniectomies and postoperative helmet molding therapy.
Methods:
A total of 100 patients with documented diagnosis of craniosynostosis were prospectively studied and treated with endoscopic strip craniectomies. A total of 106 stenosed sutures were operated on with the following distribution: 61 sagittal, 23 coronal, 18 metopic, and 4 lambdoid sutures. Sixty-three patients were treated under 16 weeks of age. After surgery, all patients were treated with custom-made molding helmets for up to 7 months. Follow-up ranged between 4 months and 50 months.
Results:
All patients underwent the surgical procedures successfully and without complications. The mean surgical operative time was 52.7 minutes. The mean estimated blood loss was 26.2 mL; only 1 patient underwent intraoperative blood transfusion, and 10 patients had a non- life-threatening postoperative blood transfusion. All but 3 patients were discharged on the first postoperative day. There were no infections, dural sinus tears, cerebrospinal fluid leaks, or neurologic injuries, and there were no significant complications related to the use of helmet therapy. Most patients have achieved or are in the process of reaching normalization of their craniofacial deformities.
Conclusions:
The results indicate that the early treatment of craniosynostosis with minimally invasive endoscopic strip craniectomies is a safe, efficacious, and valuable therapeutic alternative to the current extensive surgical treatment modalities. The significantly less blood loss, need for blood transfusions, and length of stay and decreased costs make this procedure an excellent early option for treating infants who present with craniosynostosis.

