Familial arachnoid cysts in association with autosomal dominant polycystic kidney disease

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Füsun Korkmaz Alehan1, Berkan Gürakan, Muhteşem Ağildere

  • 1Division of Child Neurology, Başkent University, Ankara, Turkey. falehan@hotmail.com

Pediatrics
|July 3, 2002
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) is linked to brain cysts. This report details a father and daughter with both ADPKD and posterior fossa arachnoid cysts, suggesting a potential familial connection.

Area of Science:

  • Nephrology
  • Neurology
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder.
  • ADPKD is known for systemic manifestations, including intracranial aneurysms.
  • Recent studies suggest an association between ADPKD and intracranial arachnoid cysts.

Purpose of the Study:

  • To report a familial occurrence of posterior fossa arachnoid cysts in patients with autosomal dominant polycystic kidney disease.
  • To highlight the potential association between ADPKD and arachnoid cysts in a family cohort.

Main Methods:

  • Case report describing a father and daughter.
  • Clinical and imaging data review for ADPKD and posterior fossa arachnoid cysts.

Main Results:

  • Both father and daughter presented with asymptomatic ADPKD.
  • Both individuals were diagnosed with a posterior fossa arachnoid cyst.
  • This represents the first reported instance of familial arachnoid cysts associated with ADPKD.

Conclusions:

  • The findings suggest a possible genetic link between ADPKD and the development of arachnoid cysts.
  • Further research is warranted to explore the underlying mechanisms and prevalence of this association.
  • This association may have implications for the clinical monitoring of ADPKD patients.

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