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Related Experiment Videos

Soluble T-lymphocyte antigen-specific immunoproteins: a progress report.

Robert E Cone1, George M Georgiou, Colin H Little

  • 1Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030-3105, USA. cone@idx.uchc.edu

Experimental Biology and Medicine (Maywood, N.J.)
|July 3, 2002
PubMed
Summary

T-cell-derived proteins that bind nominal antigen specifically (TABM) are increased in human serum during disease. These immunoproteins may modulate immunity and cytokine delivery, impacting pathogenesis.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • T-cell-derived proteins that bind nominal antigen specifically (TABM) share structural similarities with T-cell receptors (TCRs).
  • TABM proteins are present in human serum and their levels are elevated in conditions like infectious disease, chemical sensitivity, and food intolerance.

Purpose of the Study:

  • To review advances in the detection and quantification of human TABM.
  • To discuss the association between increased serum TABM and specific health conditions.
  • To explore the potential immunomodulatory mechanisms of TABM in pathogenesis.

Main Methods:

  • Detection and quantitation of human TABM using monoclonal antibodies.
  • Review of existing literature on TABM association with disease states.

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Main Results:

  • Advances in methods for detecting and quantifying human TABM have been described.
  • Increased serum TABM titers are associated with infectious disease, chemical sensitivity, and food intolerance.

Conclusions:

  • TABM proteins may influence pathogenesis by modulating cell-mediated immunity.
  • TABM may concentrate and deliver immunoregulatory cytokines, such as TGF-beta and elastase, in an antigen-specific manner.
  • The immunomodulatory action of TABM might involve antigen-specific focusing of associated cytokines.