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1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide
Rafael Tamazyan1, Harutyun Karapetyan, Ashot Martirosyan
1Molecule Structure Research Centre, National Academy of Sciences RA, Azatutyan Ave. 26, 375014 Yerevan, Republic of Armenia. rafael@msrc.am
Abstract:
The structures of two potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTI), namely 1-(2-chlorobenzoyl)-2-phenylpyrrolidine-2-carboxamide, C(18)H(17)ClN(2)O(2), and 1-(2-furoyl)-2-phenylpyrrolidine-2-carboxamide, C(16)H(16)N(2)O(3), have been investigated by X-ray diffraction and the butterfly-like conformation established in each case. The pyrrolidine ring has the same half-chair conformation in both structures.