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Opinion: Building epithelial architecture: insights from three-dimensional culture models
Lucy Erin O'Brien1, Mirjam M P Zegers, Keith E Mostov
1Department of Anatomy, and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA.
Nature Reviews. Molecular Cell Biology
|July 3, 2002
Abstract:
How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.
