[Alithiasic cholecystitis in the adult: etiologies, diagnosis and treatment]
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Updated: Sep 30, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
Published on: February 28, 2025
1Centre hépato-biliaire, hôpital Paul-Brousse, université Paris-Sud UPRES 1596, 94804 Villejuif, France.
Insights
Acalculous cholecystitis, often caused by gallbladder ischemia in critically ill patients, requires surgical removal for definitive diagnosis and treatment. Percutaneous drainage is an alternative for high-risk patients.
Area of Science:
- Gastroenterology
- Surgical Pathology
Context:
- Acalculous cholecystitis accounts for 2-14% of cholecystectomies for acute cholecystitis.
- It primarily affects critically ill patients, often with cardiovascular disease or diabetes.
- Gallbladder wall ischemia is the main etiology, though rare associations with HIV exist.
Purpose:
- To review the etiology, diagnosis, and management of acalculous cholecystitis.
- To highlight diagnostic challenges and treatment options.
Summary:
- Diagnosis is challenging due to non-specific ultrasound findings for ischemic cholecystitis.
- Cholecystectomy is the definitive treatment, providing a certain diagnosis.
- Percutaneous drainage is reserved for patients unable to undergo anesthesia; medical management alone is insufficient.
Impact:
- Clarifies the role of cholecystectomy as the gold standard treatment.
- Provides guidance on alternative management strategies for high-risk patients.
- Emphasizes the diagnostic limitations of current imaging modalities.
Abstract:
Acalculous cholecystitis represents 2% to 14% of cholecystectomies performed for acute cholecystitis. Its main etiology is ischemia of the gallbladder wall, which mainly occurs in critically ill patients, particularly in case of cardiovascular previous disease or diabetes. Acalculous cholecystitis associated with VIH are rare and have a better prognosis. Other etiologies are exceptional. Diagnosis of acalculous cholecystitis is difficult, with a lack of specificity of abdominal ultrasound for the diagnosis of ischemic cholecystitis. In all cases, cholecystectomy is a definitive treatment allowing certain diagnosis. Percutaneous drainage must be reserved to patients whose general condition does not allow general anesthesia. Medical treatment alone is not indicated in acalculous cholecystitis.
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